The tumor microenvironment represents a unique biological setting, different in many important ways from other sites of immune activity throughout the body. Through a deep understanding of the role of the tumor microenvironment in immune cell trafficking and activity, Pyxis Oncology has unlocked multiple new avenues to restore the potency of dysfunctional immune cells. Pyxis is developing a diverse pipeline of new antibodies to enhance the immune response against cancer, even in tumor types that historically have not responded well to cancer immunotherapies.